David R Newell Selected Research

NU 3153

7/2009

Preclinical evaluation of a novel pyrimidopyrimidine for the prevention of nucleoside and nucleobase reversal of antifolate cytotoxicity.

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David R Newell Research Topics

Disease

32	Neoplasms (Cancer) 12/2022 - 10/2002
5	Colorectal Neoplasms (Colorectal Cancer) 12/2016 - 01/2013
3	Neuroblastoma 01/2019 - 04/2015
3	Colonic Neoplasms (Colon Cancer) 06/2013 - 05/2006
2	Osteosarcoma (Osteogenic Sarcoma) 01/2021 - 12/2008
2	Ovarian Neoplasms (Ovarian Cancer) 09/2017 - 09/2005
2	Ataxia Telangiectasia (Louis Bar Syndrome) 06/2013 - 04/2007
2	Head and Neck Neoplasms (Head and Neck Cancer) 05/2009 - 01/2005
2	Sarcoma (Soft Tissue Sarcoma) 10/2006 - 03/2005
2	Carcinoma (Carcinomatosis) 09/2005 - 07/2003
1	Liver Neoplasms (Liver Cancer) 01/2020
1	Fibrosis (Cirrhosis) 01/2020
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2019
1	Leukemia 01/2019
1	Ewing Sarcoma (Sarcoma, Ewing) 12/2017
1	Neoplasm Metastasis (Metastasis) 01/2017
1	Adenocarcinoma 01/2016
1	Prostatic Neoplasms (Prostate Cancer) 01/2012
1	Multiple Myeloma 09/2011
1	Breast Neoplasms (Breast Cancer) 06/2011
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 07/2007

Drug/Important Bio-Agent (IBA)

8	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 01/2004
8	Temozolomide (Temodar)FDA LinkGeneric 01/2019 - 07/2003
7	Pharmaceutical PreparationsIBA 01/2020 - 03/2005
5	Phosphotransferases (Kinase)IBA 12/2022 - 04/2007
5	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2019 - 01/2013
4	EnzymesIBA 06/2020 - 07/2002
4	Poly(ADP-ribose) Polymerase InhibitorsIBA 12/2017 - 03/2007
3	Proteins (Proteins, Gene)FDA Link 01/2021 - 05/2005
3	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2020 - 06/2013
3	RG7388IBA 01/2019 - 04/2015
3	ProdrugsIBA 01/2019 - 07/2002
3	8- dibenzothiophen- 4- yl- 2- morpholin- 4- yl- chromen- 4- oneIBA 12/2017 - 05/2006
3	Biomarkers (Surrogate Marker)IBA 03/2016 - 05/2014
3	Cisplatin (Platino)FDA LinkGeneric 04/2015 - 01/2005
3	Topotecan (Hycamtin)FDA LinkGeneric 04/2015 - 07/2003
3	Etoposide (VP 16)FDA LinkGeneric 06/2013 - 05/2006
3	PoisonsIBA 06/2013 - 01/2004
2	Protein Kinases (Protein Kinase)IBA 06/2020 - 12/2017
2	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 01/2020 - 08/2012
2	DNA-Activated Protein KinaseIBA 01/2020 - 04/2007
2	AZD 6244IBA 01/2019 - 03/2016
2	rucaparibIBA 12/2017 - 09/2017
2	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 12/2017 - 06/2011
2	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 01/2017 - 09/2011
2	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 01/2017 - 09/2011
2	mirdametinibIBA 03/2016 - 01/2013
2	Small Interfering RNA (siRNA)IBA 01/2016 - 12/2008
2	Type I DNA Topoisomerases (Topoisomerase I)IBA 06/2013 - 01/2004
2	Caspase 3 (Caspase-3)IBA 01/2012 - 09/2005
2	Caspase 9IBA 01/2012 - 09/2005
2	ThymidineIBA 07/2009 - 05/2003
2	3- (4- chlorophenyl)- 3- (4- hydroxy- 3,5- dimethoxybenzyloxy)- 2- propyl- 2,3- dihydroisoindol- 1- oneIBA 10/2006 - 03/2005
2	Cytotoxins (Cytolysins)IBA 07/2003 - 11/2002
1	Mitogen-Activated Protein KinasesIBA 12/2022
1	LigandsIBA 01/2021
1	Topoisomerase InhibitorsIBA 01/2020
1	GlucocorticoidsIBA 01/2019
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2019
1	RO6839921IBA 01/2019
1	Drug CombinationsIBA 01/2019
1	Coloring Agents (Dyes)IBA 01/2018
1	4,4- difluoro- 4- bora- 3a,4a- diaza- s- indacene (BODIPY)IBA 01/2018
1	DNA Repair EnzymesIBA 12/2017
1	erdafitinibIBA 01/2017
1	dactolisibIBA 03/2016
1	Sirolimus (Rapamycin)FDA Link 03/2016
1	MTOR InhibitorsIBA 01/2016
1	SulfatasesIBA 01/2016
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2016
1	TOR Serine-Threonine KinasesIBA 01/2016
1	BIX 02189IBA 01/2016
1	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA 01/2016
1	Messenger RNA (mRNA)IBA 07/2015
1	Tumor Suppressor Protein p14ARF (p14ARF)IBA 04/2015
1	Busulfan (Busulfex)FDA Link 04/2015
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 06/2013
1	CamptothecinIBA 06/2013
1	KU59403IBA 06/2013
1	2- (1H- indazol- 4- yl)- 6- (4- methanesulfonylpiperazin- 1- ylmethyl)- 4- morpholin- 4- ylthieno(3,2- d)pyrimidineIBA 01/2013
1	alovudineIBA 01/2013
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 08/2012
1	2- (4- ethylpiperazin- 1- yl)- N- (4- (2- morpholino- 4- oxo- 4H- chromen- 8- yl)dibenzo(b,d)thiophen- 1- yl)acetamideIBA 08/2012
1	Androgen Receptors (Androgen Receptor)IBA 01/2012
1	1,2-bis(isothiazol-5-yl)disulfaneIBA 01/2012
1	Lysine (L-Lysine)FDA Link 01/2012
1	Histones (Histone)IBA 01/2012
1	NU6102IBA 09/2011
1	Cyclin-Dependent Kinase 2IBA 09/2011
1	Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA 09/2011
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 09/2011
1	Pemetrexed (MTA)FDA Link 07/2009
1	Folic Acid AntagonistsIBA 07/2009
1	NU 3153IBA 07/2009
1	NU2058IBA 05/2009
1	Apoptosis Regulatory ProteinsIBA 12/2008

Therapy/Procedure

7	Therapeutics 01/2019 - 03/2005
5	Drug Therapy (Chemotherapy) 01/2020 - 01/2004
3	Oral Administration 01/2021 - 05/2003
3	Radiotherapy 01/2020 - 01/2004